The aim of this diploma thesis, entitled "The Depot of Senses: Nature, Memory and Art in Restart," is the strategic reintegration of the former Depo tram depot in Thessaloniki through a multi-layered design approach based on three thematic axes: Nature, Memory, and Art. The Depo is a site of historical and social weight - abandoned, yet not inert. Through a dynamic adaptive reuse proposal, the project seeks to transform it from a point of neglect into an active urban cell, aiming at social reintegration and cultural promotion. To this end, the design acknowledges and strengthens the role of the Depo as a historical transportation hub, an element of industrial heritage, and a site of collective memory. The preserved building shells are respectfully reused in line with their architectural identity, housing exhibitions on the history of transportation, a library, archival materials, and research spaces. Simultaneously, the natural landscape of the Sofouli stream is reintegrated into the urban design, acting as a connective axis between people and the environment. Specifically, the theme of Nature is expressed through the "Empathy Park" - a landscape designed to activate all the senses through the experience of vegetation, sound, touch, and movement. Memory is rooted in the materiality of the structure and the historical narrative of the space, highlighting the past as a foundation for new uses. Art, finally, functions as a tool for participation and gathering: workshops, exhibitions, and cultural activities breathe new life into the space and foster paths of creative coexistence. Moreover, the design takes advantage of the Depo’s strategic location and its proximity to educational and cultural hubs, reinforcing its role as a mediating field between people and urban functions. The proposal does not treat the landscape as a passive backdrop but as an active component of the architectural experience. This thesis aspires to reintroduce the Depo as a new landmark in the city: a public space open to memory, nature, and art - but above all, open to people.