The city of Agrinio was one of the most important tobacco centers in Greece of the last century, the 20th century. The model smoke processing and storage units in the city are up to now one of the few examples of industrial architecture and generally buildings of architectural interest that can be found in the city. Although their use was doubtless industrial they are derivatives   of careful architectural design and engineering study. However, the irreversible course of reconstruction of the Greek cities with lack of legal framework for previous buildings, after World War II, did not leave unaffected the tobacco warehouses, of which a very small number continues to stand  in the city. Although today the architectural value of the remaining buildings has been recognized and all of them have been declared preserved by the Ministry of Culture, the lack of interventions for their preservation and integration into the building potential of the city has made them “dead” vacuums in the continuous structured urban fabric and their abandoned image has distorted the glory of the past. This research analyzes the historical, social and economic context in which the tobacco buildings in Agrinio were created, their architectural, structural, morphological and constructional identity, their urban role and the general interaction with the city life.