This research thesis pursues to link the myth of Persephone with urban life under pandemic conditions. The Covid-19 pandemic period is characterized by the element of change in various aspects of life, as well as the changeability of situations with continuous developments. This issue, therefore, deals with the city and its people during the pandemic as the urban experience changes and adapts in the context of collective prohibition and restrictions. At the same time, Persephone is studied as a subject of enclosure and is repositioned in the present. Although change in the myth represents the transition from one place to another, in the pandemic condition it is about the city and urban life. While observing many analogies between the present and the myth, we can consider that these elements compose the “Persephone Model”. Reference is also made to some historical and literary texts in order to analyse and accept this model. While their plot unfolds in different periods and places, they have an epidemic as common theme and are compared with the present and the myth. Locked up in the city, at home or in Hell, space changes but remains limited.