This diploma thesis presents a possible design approach to a Natural History Museum in the wider Aliakmonas River area. The proposal is based on the existing Historical-Folklore & Natural History Museum locatedin the city of Kozani. The choice of the theme came up from the desire to promote and develope the natural beauty and wealth of the region of Aliakmonas, as it is one of the richest water sources in Western Macedonia, and one of the most important habitats in the country. The Museum was located in the area of the artificial lake of Polyphytos, which crosses the river Aliakmonas, on a special bank, with the unique view of the flooded plane trees. The location is directly accessible from the main ring road. The design was influenced and guided by the surrounding space and its specific features, and was developed on two levels. The first concerns the museum building, and the second has to do with the lakeside route that ends at the circular pier. Thus, the space acquires a public character that can accommodate the locals and attract visitors, in order to get to know better the place and its natural history, both with the exhibits and functions of the museum, as well as with the walking path exploring the forest and enjoying the landscape.