In the present study we examine, through a historical, social and also architectural view, the dipolon between “health” and “psychopathy”, the psychomedical model as well as the function of the psycho-institutions. Starting with the terms of enclosing people in those institutions and considering that as a social necessity and even more a kind of discipline, we analyse the global settlement inside them. Especially, the theme is spreading in “the institutions” as the Canadian sociologist Erving Goffman named them. In the procedure of this study we describe the way of living and the circumstances under which the institutions provide their help to people. We have also presented a retrospection from ancient times till the 20th Century concerning the ways of facing “madness” during the years. A special emphasis is given to the fact that the consideration that someone is probably “psychologically ill” is based on the data which are provided from the culture of a society and are established in the whole century. The medical option is described, which is related to the currency of “psychopathy”. The psychological experiments concerning the emptiness of a human’s personality are included in our study as well, those taken place in America of ‘50s. Last but not least the reserchment is focused on the relation existing between the architecture and the “psychology”. Using the 16th century as a start there begins a retrospection that includes the first asylums, the expanding and the fading away. We reach in the end till the period of the psychiatric hospitals while on the same time we analyse architecture styles and similar constructions throughout the world.