How some bodies matter, some lives deserve protection, salvation, mourning, deserve space? Trying to answer this question we utilize various thoughts and theories on gender relations and sexuality. However, we can’t understand the processes of formation human subjects without referring to deferent scientific fields and without relating deferent parts of knowledge. Firstly, we explore the crisis of the meaning of human today, its connections with contemporary technology and war. We also present some critiques on the topic from feminist and queer aspect. Today we can see growing parts of humanity inhabiting inside a zone of indeterminacy, between human and inhuman. We make a journey to the past, at the era in which gender relations and sexuality started taking the form they have today. Going back in the Medieval Europe, we study some distinctive moments of the “History of Sexuality” comparing it with the witch hunt. We focus on biopolitical power and the “Vita Activa” so that we can see how contemporary power, through the state of exception, produces the bare life. Then, we put in the center of our study the reproduction labor and we investigate the links that connect it with family and relation. Architecture is used as a tool for this process, so we study some examples that enlightens the gender relations inside the family. How can architecture bring in surface those relations that are in crisis? Finally, we reverse this question and we ask: which are the challenges of architectural design in our times, when bigger and bigger part of the human species is expelled from humanity and does not deserve space? When architecture designs for a subject, which lives in a zone of indeterminacy, with disrupted relation, what is future going to bring to architectural design from the depths of Limbo?