The research work deals with the spatial atmospheres resulting from the combination of architecture and music, within a space. The research paper focuses on the study of the work of Iannis Xenakis and the relationship between architectural and musical composition and their connections with other sciences, with the aim of producing a special spatial atmosphere and experience. Xenakis was an architect, composer and mathematician whose work bridged the boundaries between architecture and music in an exemplary manner. His influences, experiences, and memories were sources of inspiration and played a very important role in his work. On the one hand, his approach to design and composition was based on mathematical principles that allowed him to create structures and sounds that were both innovative and deeply connected to the natural world. On the other hand, his architectural works often contained mathematical concepts and were designed to create a sense of movement and flow. The purpose of the research paper is to investigate and find, through his work, and through three interpretive tools: neurophenomenology, music notation and multisensory experience, the common expressive means and mechanisms of architecture and music, and how the two disciplines can inform and inspire each other.