The present research attempts to document the existence of climate change, making it clear that human activities are the main cause of the phenomenon. Then, reference is made to the global impacts due to climate change, such as the increase in average temperature, ice melting, rising of the sea levels and the occurrence of extreme weather events, as well as future global changes and predictions, with data referring to Greece specifically. In addition, the international effort to address the phenomenon as well as the important role and responsibility of the architect in the new data of a changing climate will be presented. Moreover, an effort is made to clarify the terms “resilience” and “urban resilience” in combination with the widely recognized term of sustainable development and the relationship between them. In conclusion, the aim of this research is the comprehension of the ominous conditions that exist in today’s societies under the threat of natural disasters, our concern and taking measures based on the design process and the investigation of ways to deal with them through the concept of resilience. This is achieved through the presentation of implemented or under research resilient examples in city or building level, given that today resilient constructions to extreme weather events is necessary to avoid costly damage to dwellings, office buildings and production facilities, and saving lives.