This research paper examines the architecture of space stations, focusing on the structural element of the module. At first, the reason of moving to space and the need of staying offworld are analyzed, in the light of the biological evolution of mankind.Through the historical retrospective of the evolution of spacecrafts, from the very first concept of the space station to the present International Space Station, we notice the prolonged use of the module in the structural configuration, as the basic unit of living and research. Hence, an attempt is made to define the concept of the module in architecture, through standardization examples, from the period of the Industrial Revolution and beyond, and then the research focuses on the design of the module in the space stations. The orbital stations of the past are analyzed, Salyut Series, Skylab and Mir, culminating in today’s International Space Station. The elements of the analysis include both the overall structure of the stations and their dimension characteristics, as well as their architectural configuration in terms of functions, but also the layout of the space inside the modules. At the same time, there is a description of the daily schedule of astronauts in the modules and how it has evolved over the years. Based on these data, comparative tables are created at the end of the paper and observations are made according to the reasons that set the module as an appropriate tool for structural configuration but also as a tool for further expansion of our extraterrestrial habitats.