This research deals with the emergence of the institution of the university, the gradual establishment of the campus and the various relationships they have developed with the urban space surrounding them. Initially, the early spatial planning models of higher education, founded during the Middle Ages in Europe, and during the 18th century in America are mentioned further in the research. Both the original ideas and the subsequent development until the 20th century on the infrastructure, the educational system and the interplay with the city based are indicated. Early academic standards were complexes of spatial planning campus for long periods.

Due to the evolution of cities and civilization, hybrid spatial planning models of campuses were born, which seize a part of the overall data that were the characteristics of the first universities to be born. Detailed examples of these hybrid forms, and also the way the design and site selection of an academic complex depending on the urban fabric are referred.

Concluding the interacting relationship between the city and the university is analyzed, and the economic, spatial and social interactive relations between the two institutions are cited.