Fashion is a field of design that is often associated with that of architecture, and seems to have been influenced by it and vice versa. During the last centuries, many architects have been concerned and engaged in the fashion design, in order sometimes to resolve issues that concerned the society, and sometimes in order to express their personal style through it. It is understood that the field of fashion is of great interest to architects as it offers the possibility of designing and creating, on a different scale, a scale that is closer to the human body and its needs, giving the possibility of artistic expression and experimentation to something more ‘’distant’’ to that of architecture. Therefore, the present research thesis, is dealing with questions and issues, such as the reasons that influence architects to design for the fashion sector, whilst presenting and analyzing a historical-theoretical framework that focuses on the 20th century architects who designed clothes. In addition, the four main points that architecture and fashion have in common, are listed and categorized. Lastly, by selecting seven architects of the 21st century, who are actively involved in fashion design and stating the reasons that led them to engage in it, an analysis of examples of their work is made, with an aim of comparing them and drawing useful conclusions from them.