The present research explores the origins of Japanese anime, its depictions’ influence from the events of World War II and the aspirations of creators/designers until today. At first, the origin of the word-concept, the expressive genre and the evolution of anime are briefly described. Atomic-era events are mentioned with an emphasis on the bombings of Hiroshima and Nagasaki, followed by bomb tests in the Pacific Ocean. Afterwards, the first of the four waves of anime creations that were shaped by historical factors, is presented. Τοthis genre belongs works that prove directly the power of atomic weapons. Then, the second wave is analyzed, which concerns the critique of the atomic age and includes works with the common theme of alternative theories about the end of the world. The third wave deals with the results of WWII and life in a post-nuclear world, while the fourth is about the side effects of the nuclear war and the influence of ideas on the Internet. Next, reference is made to major real-life disasters that affected many creators like, Agent Orange the nuclear disasters at Chernobyl and Fukushima and disasters from the spread of viruses, such as Black Plague and COVID-19. The way viruses spread is compared to the way content is spread on the internet and the danger of its reckless use is pointed out. Some examples of Japanese films and anime works capture the feeling of fear for the consequences of the imposition of technology on the human mind that is presented as an infection (virus). Finally, two aesthetic-ideological movements of creations are distinguished, Cyberpunk and Solarpunk. The first movement attempts to warn humanity, while the second one encourages humanity and suggests ways to deal with the present environmental and political problems.